Anti-DNA ligase 3 LIG3 Antibody
Boster Bio Anti-DNA ligase 3 LIG3 Antibody catalog # A02741-1. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
DNA ligase 3;6.5.1.1
Gene Name
LIG3
UniProt
P49916
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human DNA Ligase III/LIG3 (NP_039269.2) .
Clonality
Polyclonal
Tissue Specificity
Testis, thymus, prostate and heart.
Applications
WB, IHC, ICC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand- break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627) .
Molecular Weight
112907 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A02741-1
Product MSDS
https://www.bosterbio.com/msds?sku=A02741-1
Other Gene Names
DNA ligase 3
Subcellular Location
Isoform 1: Mitochondrion
Protein Name
DNA ligase 3
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