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Anti-DNA ligase 3 LIG3 Antibody

Boster Bio Anti-DNA ligase 3 LIG3 Antibody catalog # A02741-1. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

DNA ligase 3;6.5.1.1

Gene Name

LIG3

UniProt

P49916

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein of human DNA Ligase III/LIG3 (NP_039269.2) .

Clonality

Polyclonal

Tissue Specificity

Testis, thymus, prostate and heart.

Applications

WB, IHC, ICC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand- break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627) .

Molecular Weight

112907 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

DNA ligase 3

Subcellular Location

Isoform 1: Mitochondrion

Protein Name

DNA ligase 3

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