Anti-Deoxyribonuclease-1 DNASE1 Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:2251263, PubMed:11241278, PubMed:2277032) . Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity) . Among other functions, seems to be involved in cell death by apoptosis (PubMed:11241278) . Binds specifically to G- actin and blocks actin polymerization (By similarity) . Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity) . NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity) . Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity) .