Anti-HCAR2 Antibody
Boster Bio Anti-HCAR2 Antibody catalog # A02511. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Hydroxycarboxylic acid receptor 2; G-protein coupled receptor 109A; G-protein coupled receptor HM74A; Niacin receptor 1; Nicotinic acid receptor; HCAR2; GPR109A, HCA2, HM74A, NIACR1;
Gene Name
HCAR2
UniProt
Q8TDS4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human GPR109A/HM74A/HCAR2 (NP_808219.1) .
Clonality
Polyclonal
Tissue Specificity
Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.
Applications
WB, IHC, ICC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D) -beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G (i) -protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5- methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Molecular Weight
41850 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Hydroxycarboxylic acid receptor 2
Subcellular Location
Cell membrane
Protein Name
Hydroxycarboxylic acid receptor 2
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