Anti-Checkpoint protein HUS1 HUS1 Antibody

Boster Bio Anti-Checkpoint protein HUS1 HUS1 Antibody catalog # A02486. Tested in WB, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Checkpoint protein HUS1; hHUS1; HUS1;

Gene Name

HUS1

UniProt

O60921

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human HUS1

Clonality

Polyclonal

Tissue Specificity

Ubiquitous.

Applications

WB, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) . The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.