Anti-Lysine--tRNA ligase KARS Antibody
Boster Bio Anti-Lysine--tRNA ligase KARS Antibody catalog # A02479-1. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Lysine--tRNA ligase;2.7.7.-
Gene Name
KARS
UniProt
Q15046
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human LysRS/LysRS/KARS (NP_005539.1) .
Clonality
Polyclonal
Applications
WB, ICC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:9278442, PubMed:18029264, PubMed:18272479) . When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690) . Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:5338216, PubMed:14975237, PubMed:19524539, PubMed:23159739) .
Molecular Weight
68048 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A02479-1
Product MSDS
https://www.bosterbio.com/msds?sku=A02479-1
Other Gene Names
Lysine--tRNA ligase
Subcellular Location
Isoform Cytoplasmic: Cytoplasm, cytosol
Protein Name
Lysine--tRNA ligase
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