Anti-Transcription factor MafB MAFB Antibody
Boster Bio Anti-Transcription factor MafB MAFB Antibody catalog # A02446. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Transcription factor MafB; Maf-B; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B; MAFB; KRML;
Gene Name
MAFB
UniProt
Q9Y5Q3
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human MAFB.
Clonality
Polyclonal
Tissue Specificity
Ubiquitous.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:2000
Form
Liquid
Function
Acts as a transcriptional activator or repressor (PubMed:27181683) . Plays a pivotal role in regulating lineage- specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity) . Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
Molecular Weight
35792 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A02446
Product MSDS
https://www.bosterbio.com/msds?sku=A02446
Other Gene Names
Transcription factor MafB
Subcellular Location
Nucleus
Protein Name
Transcription factor MafB
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