Anti-Protein diaphanous homolog 1 DIAPH1 Antibody

Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity) . Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity) . Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity) . DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity) . Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity) . Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity) . In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466) . The MEMO1- RHOA-DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987) . It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987) . In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987) . Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987) . Plays a role in brain development (PubMed:24781755) . Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity) .