Anti-G3BP-1 (D226) Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

ATP- and magnesium-dependent helicase (PubMed:9889278) . Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278) . Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278) . Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278) . Phosphorylation-dependent sequence-specific endoribonuclease in vitro (PubMed:11604510) . Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510) . May be a regulated effector of stress granule assembly (PubMed:12642610, PubMed:20180778) .