Anti-HIF1AN Antibody
Boster Bio Anti-HIF1AN Antibody catalog # A02116-1. Tested in WB, ICC, IHC, Flow Cytometry applications. This antibody reacts with Human.
Product Specifications
Synonyms
Hypoxia-inducible factor 1-alpha inhibitor;1.14.11.30;1.14.11.n4; Factor inhibiting HIF-1; FIH-1; Hypoxia-inducible factor asparagine hydroxylase; HIF1AN; FIH1;
Gene Name
HIF1AN
UniProt
Q9NWT6
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant protein within human HIF1AN aa 1-200.
Clonality
Polyclonal
Applications
WB, ICC, IHC, Flow Cytometry
Purification
ProA affinity purified
Form
Liquid
Function
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD) . Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
Molecular Weight
40285 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A02116-1
Product MSDS
https://www.bosterbio.com/msds?sku=A02116-1
Other Gene Names
Hypoxia-inducible factor 1-alpha inhibitor
Subcellular Location
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.
Protein Name
Hypoxia-inducible factor 1-alpha inhibitor
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