Anti-PERK (R87) EIF2AK3 Antibody

Boster Bio Anti-PERK (R87) EIF2AK3 Antibody catalog # A01992-1. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Eukaryotic translation initiation factor 2-alpha kinase 3;2.7.11.1; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK; EIF2AK3; PEK, PERK;

Gene Name

EIF2AK3

UniProt

Q9NZJ5

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 56-102 of Human PERK.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. A high level expression is seen in secretory tissues.

Applications

WB, IHC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR) - induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) . Involved in control of mitochondrial morphology and function.