Anti-Protein quaking QKI Antibody
Boster Bio Anti-Protein quaking QKI Antibody catalog # A01874. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Protein quaking; Hqk; HqkI; QKI; HKQ;
Gene Name
QKI
UniProt
Q96PU8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human QKI (NP_006766.1) .
Clonality
Polyclonal
Tissue Specificity
Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients.
Applications
WB, ICC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
RNA-binding protein that plays a central role in myelinization (PubMed:16641098) . Binds to the 5'-NACUAAY-N (1,20) - UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077) . In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098) . Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity) .
Molecular Weight
37671 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Protein quaking
Subcellular Location
Nucleus . Cytoplasm .
Protein Name
Protein quaking
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