Anti-NM23-H2 NME2 Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) . Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197) . Acts as a transcriptional activator of the MYC gene; binds DNA non- specifically (PubMed:8392752, PubMed:19435876) . Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III (1) region of the MYC gene promoter. Does not bind to duplex NHE III (1) (PubMed:19435876) . Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041) . Exhibits histidine protein kinase activity (PubMed:20946858) .