Anti-Cofilin 1 (phospho-S3) CFL1 Antibody
Boster Bio Anti-Cofilin 1 (phospho-S3) CFL1 Antibody catalog # A01525S3-1. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Cofilin-1;18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform; CFL1; CFL;
Gene Name
CFL1
UniProt
P23528
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human Cofilin 1 around the phosphorylation site of Serine 3.
Clonality
Polyclonal
Tissue Specificity
Widely distributed in various tissues.
Applications
IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
IHC: 1:50-1:200
Form
Liquid
Function
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677) . Required for neural tube morphogenesis and neural crest cell migration (By similarity) .
Molecular Weight
18502 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Cofilin-1
Subcellular Location
Nucleus matrix
Protein Name
Cofilin-1
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