Anti-STAT2 Antibody
Boster Bio Anti-STAT2 Antibody catalog # A01360-2. Tested in WB, IP applications. This antibody reacts with Human.
Product Specifications
Synonyms
Signal transducer and activator of transcription 2; p113; STAT2;
Gene Name
STAT2
UniProt
P52630
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to Human STAT2.
Clonality
Polyclonal
Applications
WB, IP
Purification
ProA affinity purified
Form
Liquid
Function
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) . Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734) . Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121) .
Molecular Weight
97916 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Signal transducer and activator of transcription 2
Subcellular Location
Cytoplasm
Protein Name
Signal transducer and activator of transcription 2
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