Anti-STAT2 Antibody

Boster Bio Anti-STAT2 Antibody catalog # A01360-2. Tested in WB, IP applications. This antibody reacts with Human.

Product Specifications

Synonyms

Signal transducer and activator of transcription 2; p113; STAT2;

Gene Name

STAT2

UniProt

P52630

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic peptide, corresponding to Human STAT2.

Clonality

Polyclonal

Applications

WB, IP

Purification

ProA affinity purified

Form

Liquid

Function

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) . Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734) . Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121) .