Anti-Hepcidin HAMP Antibody

Boster Bio Anti-Hepcidin HAMP Antibody catalog # A01347. Tested in WB, IHC applications. This antibody reacts with Human, Rat.

Product Specifications

Synonyms

Hepcidin; Liver-expressed antimicrobial peptide 1; LEAP-1; Putative liver tumor regressor; PLTR; Hepcidin-25; Hepc25; Hepcidin-20; Hepc20; HAMP; HEPC, LEAP1; UNQ487/PRO1003;

Gene Name

HAMP

UniProt

P81172

Host

Rabbit

Reactivity

Human, Rat

Immunogen

Recombinant protein

Clonality

Polyclonal

Tissue Specificity

Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine.

Applications

WB, IHC

Purification

ProA affinity purified

Form

Liquid

Function

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005) .