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Anti-CRF-RI (H177) CRHR1 Antibody

Boster Bio Anti-CRF-RI (H177) CRHR1 Antibody catalog # A01298. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Corticotropin-releasing factor receptor 1; CRF-R-1; CRF-R1; CRFR-1; Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1; CRHR1; CRFR, CRFR1, CRHR;

Gene Name

CRHR1

UniProt

P34998

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 150-200 of Human CRF-RI.

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.

Applications

WB, IHC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin) . Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

Molecular Weight

50719 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A01298

Product MSDS

https://www.bosterbio.com/msds?sku=A01298

Other Gene Names

Corticotropin-releasing factor receptor 1

Subcellular Location

Cell membrane; Multi-pass membrane protein. Endosome. Agonist-binding promotes endocytosis.

Protein Name

Corticotropin-releasing factor receptor 1

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