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Anti-PDK1 Antibody

Boster Bio Anti-PDK1 Antibody catalog # A01268-2. Tested in WB, IHC, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 1, mitochondrial;2.7.11.2; Pyruvate dehydrogenase kinase isoform 1; PDH kinase 1; PDK1; PDHK1;

Gene Name

PDK1

UniProt

Q15118

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein

Clonality

Polyclonal

Tissue Specificity

Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas.

Applications

WB, IHC, IP, Flow Cytometry

Purification

ProA affinity purified

Form

Liquid

Function

Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.

Molecular Weight

49244 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A01268-2

Product MSDS

https://www.bosterbio.com/msds?sku=A01268-2

Other Gene Names

[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 1, mitochondrial

Subcellular Location

Mitochondrion matrix

Protein Name

[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 1, mitochondrial

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