Anti-SCF KITLG Antibody

Boster Bio Anti-SCF KITLG Antibody catalog # A01254-2. Tested in WB, ICC/IF, IHC, Flow Cytometry applications. This antibody reacts with Human.

Product Specifications

Synonyms

Kit ligand; Mast cell growth factor; MGF; Stem cell factor; SCF; c-Kit ligand; Soluble KIT ligand; sKITLG; KITLG; MGF, SCF;

Gene Name

KITLG

UniProt

P21583

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant protein

Clonality

Polyclonal

Applications

WB, ICC, IF, IHC, Flow Cytometry

Purification

ProA affinity purified

Form

Liquid

Function

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.