Anti-Norrin NDP Antibody
Boster Bio Anti-Norrin NDP Antibody catalog # A01045-1. Tested in WB applications. This antibody reacts with Mouse.
Product Specifications
Synonyms
Norrin; Norrie disease protein; X-linked exudative vitreoretinopathy 2 protein; NDP; EVR2;
Gene Name
NDP
UniProt
Q00604
Host
Rabbit
Reactivity
Mouse
Immunogen
Recombinant fusion protein of human NDP (NP_000257.1) .
Clonality
Polyclonal
Tissue Specificity
Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina, and in fetal and adult brain.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:2000
Form
Liquid
Function
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) . May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
Molecular Weight
15044 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Norrin
Subcellular Location
Secreted
Protein Name
Norrin
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