Anti-Na+ CP type Alpha-pan (E1476) SCN9A Antibody

Boster Bio Anti-Na+ CP type Alpha-pan (E1476) SCN9A Antibody catalog # A00920-2. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Sodium channel protein type 9 subunit alpha ; Neuroendocrine sodium channel

Gene Name

SCN9A

UniProt

Q15858

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 1442-1496 of Human Na+ CP type α-pan.

Clonality

Polyclonal

Tissue Specificity

Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion.

Applications

IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Dilution

IHC: 1:50-1:200

Form

Liquid

Function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na (+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784) . It is a tetrodotoxin-sensitive Na (+) channel isoform (PubMed:7720699) . Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784) .