Anti-Myotubularin (Y290) MTM1 Antibody
Boster Bio Anti-Myotubularin (Y290) MTM1 Antibody catalog # A00749Y290. Tested in WB, IHC applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Myotubularin; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase;3.1.3.95
Gene Name
MTM1
UniProt
Q13496
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthetic peptide, corresponding to amino acids 256-3111 of Human Myotubularin.
Clonality
Polyclonal
Applications
WB, IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI (3,5) P2) (PubMed:11001925, PubMed:10900271, PubMed:12646134, PubMed:14722070) . Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414) . Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070) . Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PubMed:21135508) . Plays a role in mitochondrial morphology and positioning (PubMed:21135508) . Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508) . In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870) .
Molecular Weight
69932 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A00749Y290
Product MSDS
https://www.bosterbio.com/msds?sku=A00749Y290
Other Gene Names
Myotubularin
Subcellular Location
Cytoplasm
Protein Name
Myotubularin
Curated Selection
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