Anti-ADAM17 Antibody
Boster Bio Anti-ADAM17 Antibody catalog # A00604-2. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Disintegrin and metalloproteinase domain-containing protein 17; ADAM 17;3.4.24.86
Gene Name
ADAM17
UniProt
P78536
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human ADAM17 (NP_003174.3) .
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
Applications
WB, IHC, ICC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) . Plays a role in the proteolytic processing of ACE2.
Molecular Weight
93021 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Disintegrin and metalloproteinase domain-containing protein 17
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Name
Disintegrin and metalloproteinase domain-containing protein 17
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