Anti-PGR (phospho-S400) Antibody
Boster Bio Anti-PGR (phospho-S400) Antibody catalog # A00541S400. Tested in WB applications. This antibody reacts with Human, Rat, Mouse.
Product Specifications
Synonyms
Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3; PGR; NR3C3;
Gene Name
PGR
UniProt
P06401
Host
Rabbit
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic phosphopeptide derived from human PGR around the phosphorylation site of Serine 400.
Clonality
Polyclonal
Tissue Specificity
In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region- specific responses to hormonal stimuli.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:1000
Form
Liquid
Function
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.
Molecular Weight
98981 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Progesterone receptor
Subcellular Location
Nucleus. Cytoplasm. Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G (1) and G (2) /M phases.
Protein Name
Progesterone receptor
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