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Anti-MLKL (phospho-S345) Antibody

Boster Bio Anti-MLKL (phospho-S345) Antibody catalog # A00535S345. Tested in IHC applications. This antibody reacts with Mouse.

Product Specifications

Synonyms

Mixed lineage kinase domain-like protein; Mlkl

Gene Name

Mlkl

UniProt

Q9D2Y4

Host

Rabbit

Reactivity

Mouse

Immunogen

Synthetic phospho-peptide corresponding to residues surrounding Ser345 of human MLKL.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in thymus, colon, intestine, liver, spleen and lung. Expressed at much lower level in skeletal muscle, heart and kidney. Not detected in brain.

Applications

IHC

Purification

ProA affinity purified

Dilution

IHC: 1:50-1:100

Form

Liquid

Function

Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

Molecular Weight

54317 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00535S345

Product MSDS

https://www.bosterbio.com/msds?sku=A00535S345

Other Gene Names

Mixed lineage kinase domain-like protein

Subcellular Location

Cytoplasm . Cell membrane . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction. .

Protein Name

Mixed lineage kinase domain-like protein

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