Anti-MLKL (phospho-S345) Antibody
Boster Bio Anti-MLKL (phospho-S345) Antibody catalog # A00535S345. Tested in IHC applications. This antibody reacts with Mouse.
Product Specifications
Synonyms
Mixed lineage kinase domain-like protein; Mlkl
Gene Name
Mlkl
UniProt
Q9D2Y4
Host
Rabbit
Reactivity
Mouse
Immunogen
Synthetic phospho-peptide corresponding to residues surrounding Ser345 of human MLKL.
Clonality
Polyclonal
Tissue Specificity
Highly expressed in thymus, colon, intestine, liver, spleen and lung. Expressed at much lower level in skeletal muscle, heart and kidney. Not detected in brain.
Applications
IHC
Purification
ProA affinity purified
Dilution
IHC: 1:50-1:100
Form
Liquid
Function
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Molecular Weight
54317 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Mixed lineage kinase domain-like protein
Subcellular Location
Cytoplasm . Cell membrane . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction. .
Protein Name
Mixed lineage kinase domain-like protein
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