Anti-RUNX-2 (N278) Antibody
Boster Bio Anti-RUNX-2 (N278) Antibody catalog # A00442-1. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Runt-related transcription factor 2; Acute myeloid leukemia 3 protein; Core-binding factor subunit alpha-1; CBF-alpha-1; Oncogene AML-3; Osteoblast-specific transcription factor 2; OSF-2; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEA2-alpha A; PEBP2-alpha A; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit; RUNX2; AML3, CBFA1, OSF2, PEBP2A;
Gene Name
RUNX2
UniProt
Q13950
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 246-297 of Human RUNX-2.
Clonality
Polyclonal
Tissue Specificity
Specifically expressed in osteoblasts.
Applications
WB, IHC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28738062, PubMed:28703881) . Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1 (I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity) . Inhibits KAT6B-dependent transcriptional activation.
Molecular Weight
56648 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A00442-1
Product MSDS
https://www.bosterbio.com/msds?sku=A00442-1
Other Gene Names
Runt-related transcription factor 2
Subcellular Location
Nucleus
Protein Name
Runt-related transcription factor 2
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