Anti-Patched (A2) PTCH1 Antibody
Boster Bio Anti-Patched (A2) PTCH1 Antibody catalog # A00441. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Protein patched homolog 1; PTC; PTC1; PTCH1; PTCH;
Gene Name
PTCH1
UniProt
Q13635
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to the N-terminal of Human Patched.
Clonality
Polyclonal
Tissue Specificity
In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin.
Applications
WB, IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH) . Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
Molecular Weight
160545 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Protein patched homolog 1
Subcellular Location
Cell membrane
Protein Name
Protein patched homolog 1
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