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Anti-Transcription factor 7-like 2 TCF7L2 Antibody

Boster Bio Anti-Transcription factor 7-like 2 TCF7L2 Antibody catalog # A00431-1. Tested in WB, ICC/IF, IHC, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Transcription factor 7-like 2; HMG box transcription factor 4; T-cell-specific transcription factor 4; T-cell factor 4; TCF-4; hTCF-4; TCF7L2; TCF4;

Gene Name

TCF7L2

UniProt

Q9NQB0

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein

Clonality

Polyclonal

Tissue Specificity

Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom.

Applications

WB, ICC, IF, IHC, IP, Flow Cytometry

Purification

ProA affinity purified

Form

Liquid

Function

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.

Molecular Weight

67919 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00431-1

Product MSDS

https://www.bosterbio.com/msds?sku=A00431-1

Other Gene Names

Transcription factor 7-like 2

Subcellular Location

Nucleus, PML body

Protein Name

Transcription factor 7-like 2

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