Anti-BACE (D492) BACE1 Antibody

Boster Bio Anti-BACE (D492) BACE1 Antibody catalog # A00322-1. Tested in IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Beta-secretase 1 ;3.4.23.46

Gene Name

BACE1

UniProt

P56817

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 480-520 of Human BACE.

Clonality

Polyclonal

Tissue Specificity

Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.

Applications

IHC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Responsible for the proteolytic processing of the amyloid precursor protein (APP) . Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves APP with much more catalytic efficiency than for the wild-type.