Anti-Polycomb complex protein BMI-1 Bmi1 Antibody
Boster Bio Anti-Polycomb complex protein BMI-1 Bmi1 Antibody catalog # A00313-1. Tested in WB, ICC/IF, IHC applications. This antibody reacts with Human, Rat.
Product Specifications
Synonyms
Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51; BMI1; PCGF4, RNF51;
Gene Name
BMI1
UniProt
P35226
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Recombinant protein
Clonality
Polyclonal
Applications
WB, ICC, IF, IHC
Purification
ProA affinity purified
Form
Liquid
Function
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373) . The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358) . In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249) .
Molecular Weight
36949 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Polycomb complex protein BMI-1
Subcellular Location
Nucleus
Protein Name
Polycomb complex protein BMI-1
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