What is the catalog number for Anti-MITF Antibody?

The catalog number for Anti-MITF Antibody is A00269-1.

What sizes are available for Anti-MITF Antibody?

Anti-MITF Antibody is available in the following size(s): 100 µL.

Is Anti-MITF Antibody in stock?

Anti-MITF Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-MITF Antibody?

The safety data sheet for Anti-MITF Antibody is available here: https://www.bosterbio.com/msds?sku=A00269-1.

Anti-MITF Antibody

Boster Bio Anti-MITF Antibody catalog # A00269-1. Tested in WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Microphthalmia-associated transcription factor; Class E basic helix-loop-helix protein 32; bHLHe32; MITF; BHLHE32;

Gene Name

MITF

UniProt

O75030

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein of human MITF (NP_937801.1) .

Clonality

Polyclonal

Tissue Specificity

Isoform M is exclusively expressed in melanocytes and melanoma cells. Isoform A and isoform H are widely expressed in many cell types including melanocytes and retinal pigment epithelium (RPE) . Isoform C is expressed in many cell types including RPE but not in melanocyte-lineage cells. Isoform Mdel is widely expressed in melanocytes, melanoma cell lines and tissues, but almost undetectable in non-melanoma cell lines.

Applications

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Dilution

WB: 1:500-1:2000

Form

Liquid

Function

Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR) . Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) . Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.