Anti-TSC2 (phospho-T1462) Antibody

Boster Bio Anti-TSC2 (phospho-T1462) Antibody catalog # A00229T1462-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4;

Gene Name

TSC2

UniProt

P49815

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to residues in Human TSC2 around the phosphorylation site of Thr1462.

Clonality

Polyclonal

Tissue Specificity

Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.

Applications

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Dilution

WB: 1:500-1:1000

Form

Liquid

Function

In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400) . Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059) . May also play a role in microtubule-mediated protein transport (By similarity) . Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity) .