Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-p27 Kip1 (phospho-T198) CDKN1B Antibody

Selected Variant

A00173T198

Size: 100 µL

Boster Bio Anti-p27 Kip1 (phospho-T198) CDKN1B Antibody catalog # A00173T198. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27

Gene Name

CDKN1B

UniProt

P46527

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic phosphopeptide derived from human p27 Kip1 around the phosphorylation site of Threonine 198.

Clonality

Polyclonal

Tissue Specificity

Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Dilution

WB: 1:500-1:1000

Form

Liquid

Function

Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995) . Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A- CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

Molecular Weight

22073 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Cyclin-dependent kinase inhibitor 1B

Subcellular Location

Nucleus. Cytoplasm. Endosome . Nuclear and cytoplasmic in quiescent cells. AKT- or RSK- mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen- activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity) . .

Protein Name

Cyclin-dependent kinase inhibitor 1B

Price

Sign In for Pricing

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Anti-ABCG1 Antibody Picoband®, iFluor647 Conjugate
PA1868-iFluor647 100 µg

Anti-ABCG1 Antibody Picoband®, iFluor647 Conjugate

Sign In for Pricing
View Details
HSP27 (HSPB1/774), 0.2mg/mL
BNUB0774-100 1x 100 µL

HSP27 (HSPB1/774), 0.2mg/mL

Sign In for Pricing
View Details
C1QB / Complement C1q B-Chain (C1QB/2966), 1mg/mL
BNUM2966-50 1x 50 µL

C1QB / Complement C1q B-Chain (C1QB/2966), 1mg/mL

Sign In for Pricing
View Details
P57 / KIP2 (KP10 + KIP2/880), CF740 conjugate, 0.1mg/mL
BNC741015-100 1x 100 µL

P57 / KIP2 (KP10 + KIP2/880), CF740 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
AMACR / p504S (Rabbit PAb), CF568 conjugate, 0.1mg/mL
BNC680731-500 1x 500 µL

AMACR / p504S (Rabbit PAb), CF568 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Renal Cell Carcinoma (Carbonic Anhydrase IX) (CA9/2993R), CF488A conjugate, 0.1mg/mL
BNC882993-100 1x 100 µL

Renal Cell Carcinoma (Carbonic Anhydrase IX) (CA9/2993R), CF488A conjugate, 0.1mg/mL

Sign In for Pricing
View Details