Anti-Smad2/3 (Phospho-T8) Antibody
Boster Bio Anti-Smad2/3 (Phospho-T8) Antibody catalog # A00090T8. Tested in WB applications. This antibody reacts with Human, Rat, Mouse.
Product Specifications
Synonyms
Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2; SMAD2; MADH2, MADR2;
Gene Name
SMAD2
UniProt
Q15796/P84022
Host
Rabbit
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic phosphopeptide derived from human Smad2/3 around the phosphorylation site of Threonine 8.
Clonality
Polyclonal
Tissue Specificity
Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:1000
Form
Liquid
Function
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Molecular Weight
52306 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Mothers against decapentaplegic homolog 2
Subcellular Location
Cytoplasm
Protein Name
Mothers against decapentaplegic homolog 2
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