Anti-Smad2 (Phospho-S255) Antibody
Boster Bio Anti-Smad2 (Phospho-S255) Antibody catalog # A00090S255. Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2; SMAD2; MADH2, MADR2;
Gene Name
SMAD2
UniProt
Q15796
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phospho-peptide corresponding to residues surrounding Ser255 of human Smad2.
Clonality
Polyclonal
Tissue Specificity
Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.
Applications
WB, IHC, IP
Purification
ProA affinity purified
Form
Liquid
Function
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Molecular Weight
52306 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Mothers against decapentaplegic homolog 2
Subcellular Location
Cytoplasm
Protein Name
Mothers against decapentaplegic homolog 2
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