Anti-VHL Antibody

Boster Bio Anti-VHL Antibody catalog # A00079-1. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Mouse, Rat.

Product Specifications

Synonyms

Von Hippel-Lindau disease tumor suppressor; Protein G7; pVHL; VHL;

Gene Name

VHL

UniProt

P40337

Host

Rabbit

Reactivity

Mouse, Rat

Immunogen

A synthetic peptide of human VHL (NP_937799.1) .

Clonality

Polyclonal

Tissue Specificity

Expressed in the adult and fetal brain and kidney.

Applications

WB, IHC, ICC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.

Molecular Weight

24153 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Von Hippel-Lindau disease tumor suppressor

Subcellular Location

Isoform 1: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane.