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Anti-Bcl-2 (phospho-T69) Antibody

Boster Bio Anti-Bcl-2 (phospho-T69) Antibody catalog # A00040T69. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Apoptosis regulator Bcl-2; BCL2;

Gene Name

BCL2

UniProt

P10415

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic phosphopeptide derived from human Bcl-2 around the phosphorylation site of Threonine 69.

Clonality

Polyclonal

Tissue Specificity

Expressed in a variety of tissues.

Applications

IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Dilution

IHC: 1:50-1:200

Form

Liquid

Function

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785) .

Molecular Weight

26266 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00040T69

Product MSDS

https://www.bosterbio.com/msds?sku=A00040T69

Other Gene Names

Apoptosis regulator Bcl-2

Subcellular Location

Mitochondrion outer membrane

Protein Name

Apoptosis regulator Bcl-2

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