Anti-Bcl-2 (phospho-T69) Antibody
Boster Bio Anti-Bcl-2 (phospho-T69) Antibody catalog # A00040T69. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Apoptosis regulator Bcl-2; BCL2;
Gene Name
BCL2
UniProt
P10415
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human Bcl-2 around the phosphorylation site of Threonine 69.
Clonality
Polyclonal
Tissue Specificity
Expressed in a variety of tissues.
Applications
IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
IHC: 1:50-1:200
Form
Liquid
Function
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785) .
Molecular Weight
26266 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Apoptosis regulator Bcl-2
Subcellular Location
Mitochondrion outer membrane
Protein Name
Apoptosis regulator Bcl-2
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