CM764
CM764 is an activator for sigma receptor with Ki of 86.6 and 3.5 nM for sigma-1 receptor and sigma-2 receptor. CM764 increases cytoplasmic calcium, NAD+/NADH, and ATP levels, and decreases the concentration of ROS[1].
Product Specifications
CAS Number
1350296-29-5
UNSPSC
12352005
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cm764.html
Smiles
O=C1OC2=CC(C(C)=O)=CC=C2N1CCCCN3CCN(C4=CC=C(F)C=C4N)CC3
Molecular Formula
C23H27FN4O3
Molecular Weight
426.48
References & Citations
[1]Nicholson H, et al., Sigma-2 Receptors Play a Role in Cellular Metabolism: Stimulation of Glycolytic Hallmarks by CM764 in Human SK-N-SH Neuroblastoma. J Pharmacol Exp Ther. 2016 Feb;356 (2) :232-43.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Sigma 1 Receptor; Sigma 2 Receptor
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