PI3Kα-IN-21
Product Specifications
UNSPSC Description
PI3Kα-IN-21 (compound 8) is a PI3Kα inhibitor, and its selectivity for PI3Kα is 10.41/16.99/37.53 times higher than PI3Kβ/γ/δ respectively (IC50: 96.89/568.24/397.48 nM ). PI3Kα-IN-21 inhibits cancer cell activity, proliferation, and migration, and induces mitochondrial apoptosis through the PI3K/Akt/mTOR pathway. PI3Kα-IN-21 exhibits in vivo antitumor potency in a mouse model of non-small cell lung cancer[1].
Target Antigen
Apoptosis; PI3K
Type
Reference compound
Related Pathways
Apoptosis;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/pi3kα-in-21.html
Solubility
10 mM in DMSO
Smiles
CC1=NC2=C(C(N(C3=CC=C4C(/C(C(N4CC5=CC=CC=C5)=O)=C/C6=CC=CC=C6)=C3)CC7=CC=CC=C7)=N1)C=CC=C2
Molecular Weight
558.67
References & Citations
[1]Liu C, et al. Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3Kα inhibitors. J Adv Res. 2024 Mar 11:S2090-1232(24)00089-4.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-158029/PI3Kα-IN-21-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-158029/
Clinical Information
No Development Reported
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