NM107

NM107 (2'-C-Methylcytidine) is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, the EC50 of NM107 in the wild-type replicon cells is 1.85 μM[1][2].

Product Specifications

CAS Number

[20724-73-6]

Product Name Alternative

2'-C-Methylcytidine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HCV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/NM107.html

Concentration

10mM

Purity

99.90

Solubility

H2O : ≥ 50 mg/mL

Smiles

OC[C@@H]1[C@@H](O)[C@](O)(C)[C@H](N2C(N=C(N)C=C2)=O)O1

Molecular Formula

C10H15N3O5

Molecular Weight

257.24

Precautions

H302, H315, H319, H335

References & Citations

[1] Mathy JE, et al, Combinations of cyclophilin inhibitor NIM811 with hepatitis C Virus NS3-4A Protease or NS5B polymerase inhibitors enhance antiviral activity and suppress the emergence of resistance. Antimicrob Agents Chemother. 2008 Sep;52 (9) :3267-75.|[2]Guedj J, et al. Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life. Proc Natl Acad Sci U S A. 2013 Mar 5;110 (10) :3991-6.