P-Cresol sulfate-d7 (potassium)

P-Cresol sulfate-d7 (p-Tolyl sulfate-d7) potassium is the deuterium labeled p-Cresyl sulfate potassium. p-Tolyl sulfate is a uremic toxin, that can cause renal damage and dysfunction. p-Cresyl sulfate shows antiproliferation activity. p-Cresyl sulfate increases the protein expression of HIF-1α and VHL, decreases the protein expression of HIF-2α. p-Cresyl sulfate induces epithelial-mesenchymal transition (EMT) . p-Cresyl sulfate activates the JNK and p38 MAPK signaling pathways[1][2][3].

Product Specifications

CAS Number

[2469278-96-2]

Product Name Alternative

P-Tolyl sulfate-d7 (potassium)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Isotope-Labeled Compounds; JNK; p38 MAPK; Reactive Oxygen Species (ROS)

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Metabolic Disease

Purity

99.8

Solubility

10 mM in DMSO

Smiles

O=S(OC1=C([2H])C([2H])=C(C([2H])([2H])[2H])C([2H])=C1[2H])(O[K])=O

Molecular Formula

C7D7KO4S

Molecular Weight

233.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Wu TK, et al. The uremic toxin p-cresyl sulfate induces proliferation and migration of clear cell renal cell carcinoma via microRNA-21/ HIF-1α axis signals. Sci Rep. 2019 Mar 1;9 (1) :3207.|[2]Koppe L, et al. p-Cresyl sulfate promotes insulin resistance associated with CKD. J Am Soc Nephrol. 2013 Jan;24 (1) :88-99.|[3]Tanaka H, et al. p-Cresyl sulfate induces osteoblast dysfunction through activating JNK and p38 MAPK pathways. Bone. 2013 Oct;56 (2) :347-54.