PROTAC PARP1 degrader-1

PROTAC PARP1 degrader-1 (Compound CN0) is a PROTAC degrader of PARP1. PROTAC PARP1 degrader-1 activates the cGAS/STING immunity pathway and eventually enhances T cell killing of tumor cells. PROTAC PARP1 degrader-1 inhibits DNA damage repair, resulting in highly efficient accumulation of cytosolic DNA fragments (Blue: CRBN ligand, Black: linker; Pink: PARP1 inhibitor) [1].

Product Specifications

UNSPSC

12352005

Target

PARP; PROTACs

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; PROTAC

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/protac-parp1-degrader-1.html

Purity

99.86

Solubility

10 mM in DMSO

Smiles

NC(C1=CC=CC2=CN(N=C21)C3=CC=C(C=C3)C4CN(CCC4)C5=C(C6=CC=C5)C(N(C6=O)C7CCC(NC7=O)=O)=O)=O

Molecular Formula

C32H28N6O5

Molecular Weight

576.60

References & Citations

[1]Lin S, et al. Discovery of CN0 as a novel proteolysis-targeting chimera (PROTAC) degrader of PARP1 that can activate the cGAS/STING immunity pathway combined with daunorubicin. Bioorg Med Chem. 2022 Sep 15;70:116912.