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CDK2-IN-22

CDK2-IN-22 (compound 7I) is a potent CDK2 inhibitor with an IC50 of 64.42 nM. CDK2-IN-22 presents a broad antiproliferative efficacy toward diverse cancer cells MV4-11, HT-29, MCF-7, and HeLa with IC50 values of 0.83 μM, 2.12 μM, 3.12 μM, and 8.61 μM, respectively[1].

Product Specifications

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk2-in-22.html

Purity

98.64

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(NC2=NC=CC(NC3=CC(OC4=CC=CC=C4)=CN=C3)=N2)C=C1)(N)=O

Molecular Formula

C21H18N6O3S

Molecular Weight

434.47

References & Citations

[1]Wen-Bin Zeng, et al. Design, synthesis, and biological evaluation of N- (pyridin-3-yl) pyrimidin-4-amine analogues as novel cyclin-dependent kinase 2 inhibitors for cancer therapy. Bioorg Chem. 2024 Feb:143:107019.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK2

Available Sizes

Frequently Asked Questions

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