APP-018

APP-018 (D-4F) is 18 D-amino acids peptide that mimics apolipoprotein A-I (apoA-I) . APP-018 improves the anti-inflammatory activity of high-density lipoprotein (HDL) . APP-018 can be used in researches of cardiovascular diseases[1].

Product Specifications

CAS Number

[452782-06-8]

Product Name Alternative

D-4F

UNSPSC

12352209

Target

Apolipoprotein

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/app-018.html

Purity

99.80

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C([C@H](C(N[C@H](CC1=CC=CC=C1)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](CC2=CC=C(O)C=C2)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](CC3=CC=CC=C3)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](CC4=CC=CC=C4)C(N)=O)=O)C)=O)CCC(O)=O)=O)CCCCN)=O)=O)CCCCN)=O)CCC(O)=O)=O)C)=O)C(C)C)=O)CCCCN)=O)CC(O)=O)=O)=O)CC5=CC=CC=C5)=O)C)=O)CCCCN)=O)=O)NC([C@@H](CC(O)=O)NC(C)=O)=O)C=6C=7C(NC6)=CC=CC7

Molecular Formula

C114H156N24O28

Molecular Weight

2310.60

References & Citations

[1]Bloedon LT, et al., Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients. J Lipid Res. 2008 Jun;49 (6) :1344-52.