EGR-1-IN-1
EGR-1-IN-1 (IT25) is an inhibitor targeting EGR-1, with IC50 of 1.86 μM. EGR-1-IN-1 can be used in the research of inflammatory skin diseases[1].
Product Specifications
UNSPSC
12352005
Target
DNA Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/egr-1-in-1.html
Purity
98.11
Solubility
DMF : 1.25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
COC1=CC2=C(/C(C(N2)=O)=N/NC(NC3=CC=C(C=C3)C#N)=S)C=C1
Molecular Formula
C17H13N5O2S
Molecular Weight
351.38
References & Citations
[1]Ahn S, et al. Design, synthesis, and biological evaluation of 2- (2-oxoindolin-3-ylidene) hydrazinecarbothioamides as a potential EGR-1 inhibitor for targeted therapy of atopic dermatitis. Bioorg Chem. 2024 Jul;148:107481.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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