TGF-β1/Smad3-IN-1
TGF-β1/Smad3-IN-1 (Compound 5aa) is an inhibitor of the TGF-β1/Smad3 signaling pathway (IC50=1.07 μM) . TGF-β1/Smad3-IN-1 possesses antifibrotic activity and oral potency[1].
Product Specifications
UNSPSC
12352005
Target
TGF-beta/Smad
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tgf-β1-smad3-in-1.html
Purity
98.05
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N4CCN(C)CC4)C=C3)/C5=CC=CC=C5)OC.CCS(=O)(O)=O
Molecular Formula
C30H34N4O6S
Molecular Weight
578.68
References & Citations
[1]An B, et al. Inhibition of TGF-β1/Smad3 signaling by compound 5aa: A potential treatment for idiopathic pulmonary fibrosis. Bioorg Chem. 2024 Apr 16;147:107374.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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