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Cephradine

Cephradine (Cefradine) is a broad-spectrum and orally active cephalosporin. Cephradine is active against both gram-positive and gram-negative pathogens. Cephradine is effective in eradicating most penicillinase-producing organisms. Cephradine has been used in the research of genitourinary, gastrointestinal and respiratory tract infections, and in infections of the skin and soft tissues. Cephradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of TOPK[1][2][3].

Product Specifications

CAS Number

38821-53-3

Product Name Alternative

Cefradine; SQ-11436

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H334, H335

Target

Antibiotic; Bacterial; TOPK

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Cefradine.html

Purity

95.11

Solubility

DMSO : ≥ 3.6 mg/mL|H2O : 8.33 mg/mL (ultrasonic)

Smiles

O=C(C(N12)=C(C)CS[C@]2([H])[C@H](NC([C@H](N)C3=CCC=CC3)=O)C1=O)O

Molecular Formula

C16H19N3O4S

Molecular Weight

349.40

Precautions

H315, H317, H319, H334, H335

References & Citations

[1]Schwinghammer TL, et al. Pharmacokinetics of cephradine administered intravenously and orally to young and elderly subjects. J Clin Pharmacol. 1990;30 (10) :893-899|[2]Caloza DL Jr, et al. Intravenous use of cephradine and cefazolin against serious infections. Antimicrob Agents Chemother. 1979;15 (1) :119-122.|[3]Fan X, et al. Cefradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of T-LAK cell-originated protein kinase. Oncotarget. 2016;7 (17) :24633-24645|[4]Kang S, et al. In Vitro and In Vivo Antimicrobial Activity of Antibiotic-Conjugated Carriers with Rapid pH-Responsive Release Kinetics. Adv Healthc Mater. 2019;8 (14) :e1900247.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

β-lactam

Available Sizes

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