IMAB027

IMAB027 (ASP1650) is a specific anti-CLDN6 mAb, while CLDN6 (Claudin 6) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6+ ovarian and testicular cancer cell lines[1].

Product Specifications

CAS Number

[1650599-68-0]

Product Name Alternative

ASP1650

UNSPSC

12352203

Target

HCV

Type

Inhibitory Antibodies

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/imab027.html

Purity

99.89

Solubility

10 mM in DMSO

Smiles

[IMAB027]

Molecular Weight

(144.42 kDa)

References & Citations

[1]Türeci Ö, t al. The anti-claudin 6 antibody, IMAB027, induces antibody-dependent cellular and complement-dependent cytotoxicity in claudin 6-expressing cancer cells[J]. Cancer Research, 2018, 78 (13_Supplement) : 882-882.