Lomefloxacin (hydrochloride) (Standard)

Lomefloxacin (hydrochloride) (Standard) is the analytical standard of Lomefloxacin hydrochloride (HY-B0455) . This product is intended for research and analytical applications. Lomefloxacin hydrochloride (NY-198 hydrochloride) is an orally active difluoroquinolone antibiotic. Lomefloxacin hydrochloride prevents DNA supercoiling and replication by inhibiting bacterial topoisomerase II. Lomefloxacin hydrochloride induces ROS production and Apoptosis. Lomefloxacin hydrochloride has broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria. Lomefloxacin hydrochloride has anticancer effects against melanoma. Lomefloxacin hydrochloride can be used in the study of systemic bacterial infections (such as Salmonella typhimurium infections), skin and melanoma [1][2][3][4][5][6].

Product Specifications

CAS Number

[98079-52-8]

Product Name Alternative

SC47111A (hydrochloride) (Standard) ; NY-198 (hydrochloride) (Standard)

UNSPSC

12352005

Target

Antibiotic; Apoptosis; Bacterial; Reactive Oxygen Species (ROS) ; Reference Standards; Topoisomerase

Type

Reference Standards

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Cancer; Infection; Endocrinology

Assay Protocol

https://www.medchemexpress.com/lomefloxacin-hydrochloride-standard.html

Smiles

CCN(C=C(C(O)=O)C1=O)C(C1=CC(F)=C2N(CCN3)CC3C)=C2F.Cl

Molecular Formula

C17H20ClF2N3O3

Molecular Weight

387.81

References & Citations

[1]Reem I Al-Wabli. Lomefloxacin. Profiles Drug Subst Excip Relat Methodol. 2017;42:193-240.|[2]Hoogkamp-Korstanje JA. In-vitro activities of ciprofloxacin, levofloxacin, lomefloxacin, ofloxacin, pefloxacin, sparfloxacin and trovafloxacin against gram-positive and gram-negative pathogens from respiratory tract infections. J Antimicrob Chemother. 1997 Sep;40 (3) :427-31.